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Medical University of Bialystok

Clinical Research Centre

The Personalised Medicine Unit – clinical and scientific research into diabetes, obesity and metabolic disorders.

ul. M. Skłodowskiej-Curie 24a · 15-276 Białystok · cbk@umb.edu.pl

Current clinical-study recruitment
About

The Clinical Research Centre of the Medical University of Bialystok comprises six specialised units: the Laboratory of Genomics and Epigenetic Analyses, the Laboratory of Metabolomics, the Personalised Medicine Unit, the Laboratory of Computational Molecular Medicine, the Laboratory of Bioinformatics and Multi-omic Analyses, and the Laboratory of Physical Activity Research. This site is dedicated to the Personalised Medicine Unit.

The Unit brings together specialists from many fields: physicians, laboratory diagnosticians and nurses, as well as biotechnologists, biologists, chemists and dietitians. We combine direct patient care with advanced laboratory analysis, creating a place where research genuinely translates into treatment.

News

News

Information for patients

Dear Patients, recruitment for studies involving measurements in the metabolic chambers is now closed. Stay tuned for updates.

Have questions? Write to us.

August 2026
Dzień Dobry TVN

Metabolic chambers on “Dzień Dobry TVN”

The metabolic chambers at the MUB Clinical Research Support Centre were visited by the “Dzień Dobry TVN” crew. They are the first chambers of their kind in Poland and among roughly twenty of this class worldwide. They host patient studies on metabolic diseases – diabetes and obesity.

“The results are very interesting,” Prof. Adam Krętowski, MUB Vice-Rector for digital medicine and clinical research, told journalist Sylwia Cizla. More on the metabolic chambers coming soon on TVN.

March 2026
Clinical Research Support Centre

Studies in the metabolic chambers have begun

In March 2026, two metabolic chambers were officially opened at the MUB Clinical Research Support Centre – the first research infrastructure of this kind in Poland. They are sealed rooms in which a participant's energy expenditure and metabolism are measured with great precision.

The first measurements are already under way in the chambers, as part of the Unit's ongoing research projects – including studies on diabetes, obesity and the effectiveness of new therapies.

November 2025
GAROS project

Thank you for taking part in the GAROS project

The Clinical Research Centre team sincerely thanks all patients who took part in the GAROS project. Thanks to your commitment and trust, we gathered an impressive amount of data – 1,100 patients took part in the study.

We are beginning a detailed analysis of the results, which will help us better understand key aspects of health and develop more effective diagnostic and therapeutic methods. We also remind you about follow-up visits – an important part of monitoring the project and your health.

May 2025
26th PTD Congress, Kraków

The CRC team at the Polish Diabetes Association Congress

The MUB Clinical Research Centre team took part in the 26th Congress of the Polish Diabetes Association (8–10 May 2025, Kraków). In the Basic Science and Genetics section, Prof. Michał Ciborowski spoke about individualising physical activity as part of precision therapy in type 2 diabetes and metabolic syndrome (on behalf of Prof. Adam Krętowski), while Dr Łukasz Szczerbiński presented modern precision-medicine approaches to preventing and treating type 2 diabetes.

During the short oral-presentation session, Dr Maciej Szabłowski presented preliminary results from the GAROS study – on the effect of short-term semaglutide treatment on glucose variability (CGM) in patients with prediabetes and obesity.

Research projects

National and international research

The Unit runs numerous national and international projects in cooperation with leading research centres in Poland and worldwide.

PolReD

Stop Diabetes!

The Polish Diabetes Registry – the country's largest registry of patients with diabetes and people at high risk of developing it. Using state-of-the-art molecular methods and artificial intelligence, we search for new ways to prevent diabetes and slow its progression.

GAROS

Genetics of the response to semaglutide treatment

Genetics of the Acute Response to Oral Semaglutide. The project searches for genetic variants associated with the metabolic response to short-term oral semaglutide treatment in patients with obesity and prediabetes.

BBSS

Bialystok Bariatric Surgery Study

One of the first and largest registries of patients undergoing bariatric surgery in Poland. This unique study follows patients for several years after surgery – we investigate the mechanisms of diabetes and obesity remission and build algorithms to predict the response to surgery.

Laboratories and infrastructure

From the patient
to molecular analysis

We have a clinical area designed for working with patients – our own blood-collection points, a procedure room, an anthropometric analysis lab with body-composition analysers and a densitometer, and an exercise-testing lab. We also run an Analytical Laboratory performing immunochemical, biochemical, radioisotope and molecular-biology assays.

Facilities

Our facilities

We combine clinical and analytical work across several specialised facilities – from exercise testing, through metabolic measurements, to molecular and mitochondrial analyses. Each covers a different piece of the same puzzle: understanding how human metabolism works.

Exercise Testing Lab

Exercise tests and ergospirometry (CPET). We assess fitness, gas exchange and the cardiovascular and respiratory response to exercise.

Metabolism Research Lab

Metabolic chambers (WRIC) and resting-metabolism measurement. We study energy expenditure and how the body uses substrates.

Mitochondrial Analysis Lab

High-resolution cellular respiration (Oroboros O2k) and Seahorse XF assays. We assess mitochondrial function and capacity.

Biochemical Analysis Lab

Immunoenzymatic (ELISA/DYNEX) and biochemical assays. Quantitative analysis of biomarkers from blood, urine and tissue.

Body Composition Lab

Densitometry (DXA) and bioimpedance analysis (InBody). Precise measurement of fat, muscle and bone mass.

Molecular Biology Lab

Isolation and analysis of nucleic acids, gene-expression and genetic-variant studies for precision medicine.

For patients

Patient resources

The materials above are for information and education only. They do not replace a consultation or the individual advice of your treating physician.

Sports medicine diagnostics

Comprehensive fitness and health diagnostics – in controlled, safe conditions, using professional equipment.

Equipment

  • Cycle ergometer (Wingate test, CPET)
  • Treadmill with gas-exchange analyser – ergospirometer
  • DXA densitometer
  • InBody body-composition analyser
  • ECG machine
  • Echocardiograph (heart ultrasound)
  • Laboratory facilities

Scope of tests

  • Wingate test
  • Spirometry
  • CPET – exercise test per protocols
  • DXA – densitometry
  • InBody – body-composition analysis
  • Biochemical and haematological tests
  • ECG and heart echo (cardiologist, with report)

By choosing our services, you support the development of research carried out in public institutions.

Exercise tests are performed in the presence of medical and technical staff. ECG and heart echo are reported by a cardiologist. You can be sure your tests are carried out in controlled conditions.

Packages

Choose a ready-made package or build your own set of tests below.

Returning to activity

For people returning to activity after a break, injury or illness.

PLN 000–000
Fitness & physique

For people looking after their fitness and body composition.

PLN 000–000
Amateur athlete

For regularly training amateurs.

PLN 000–000
Competitive / elite

For competitors and those training at an elite level.

PLN 000–000

Build your own set and order

Provide a phone number or email – we will contact you about scheduling.

Team

Leadership

Head of the Clinical Research Centre

prof. dr hab. n. med. Adam Jacek Krętowski

Specialist in diabetology, endocrinology and internal medicine, Rector of the Medical University of Bialystok. He heads the Department of Endocrinology, Diabetology and Internal Medicine and acts as head of the Clinical Research Centre. He was awarded the title of professor in 2006; in 2005–2007 he was a Visiting Associate Professor at the Barbara Davis Center for Childhood Diabetes (University of Colorado, Denver).

Initiator of MUB's strategic research investments – including the Clinical Research Centre and the molecular-imaging and bioinformatics laboratories – supporting the development of genomics, biobanking, personalised medicine and artificial intelligence.

Selected publications
Full list of publications on Google Scholar ↗
Team leader · Personalised Medicine Unit

dr Łukasz Szczerbiński

Affiliated with the Department of Endocrinology and the MUB Clinical Research Centre. He specialises in genetics and precision medicine in type 2 diabetes – studying how genetic variants affect treatment response. He conducts research in collaboration with, among others, Harvard Medical School and the National Institutes of Health in the USA.

Selected publications
+48 85 831 81 56
Full list of publications on Google Scholar ↗
Team

Team research team

An interdisciplinary team of physicians, study coordinators, scientists and data analysts carrying out the Clinical Research Centre's projects.

Head of the Metabolism Research Group
prof. Steen Larsen
Head of the Metabolism Research Group
Author of over 100 publications (including Diabetologia, Nature Communications, Acta Physiologica). His work focuses on integrative human physiology and the effect of exercise, diet and pharmacotherapy on metabolism and mitochondrial function.
Clinical group
mgr Anna Citko-Rojewska
Team manager · study coordinator · medical analyst
Oversees the conduct of scientific and clinical studies and coordinates the work of scientific and clinical staff.
mgr Paulina Szafran
Clinical and scientific study coordinator
Prepares and oversees study protocols and the flow and integration of clinical data, including in commercial projects.
mgr n. farm. Anna Wysocka
Commercial-study coordinator
A member of the Clinical Research Support Centre; runs projects at the CRC and in the University Hospital clinics, ensuring compliance with standards.
mgr Maciej Hryń
Clinical-study coordinator
Coordinates commercial studies and maintains ongoing cooperation with the research team.
mgr Iwona Tomaszewska
Clinical-study coordinator
Supports the coordination team; responsible for labelling, shipping and handling sample results in commercial studies.
mgr Aleksandra Sadowska
Study-participant support specialist
Responsible for patient registration and administering enrolment for scientific and clinical studies.
mgr Agata Mroczkowska
Participant administrative-support specialist
Patient registration, collecting interview data, and organising and archiving documentation.
lek. Bartosz Pomichter
Endocrinologist, physician in training
Takes part in clinical care and in conducting the team's studies.
lek. Maciej Szabłowski
Endocrinologist, physician in training
Takes part in clinical care and in conducting the team's studies.
mgr Iwona Waszkiewicz
Nursing specialist
Responsible for the correct collection and initial processing of biological material obtained from patients.
Scientific group
mgr Agata Szklaruk
Biologist, dietitian
Designs part of the nutrition studies and analyses nutritional, statistical and energy-requirement data.
mgr Weronika Karpowicz
Chemist
Integrates patient data with databases and performs anthropometric measurements; trained in radiation protection.
mgr inż. Adam Paszko
PhD student, researcher
Molecular and biochemical analysis of samples, mitochondrial analysis and analysis of metabolic data.
dr Aleksandra Golonko
Metabolism research group
Collects and analyses data on the body's energy expenditure.
dr Gladys Wojciechowska
Researcher, scientist
Predicting type 2 diabetes remission after sleeve gastrectomy using clinical data, microRNA and machine learning.
Data analysis and integration group
mgr Adrian Janucik
Biostatistics and databases specialist
Responsible for analysing and integrating data acquired during studies.
mgr Zofia Urbaniak
Biostatistician, data analyst
Preparation and statistical analysis of data collected within projects.
mgr Gabriela Górska
Biostatistician, data analyst
Preparation and statistical analysis of data collected within projects.
mgr Dawid Kośko
Biostatistician
Statistical preparation and interpretation of results obtained during studies.
mgr inż. Izabela Kartowicz-Stolarska
Information systems and networks specialist
Designs and maintains IT solutions supporting the team's research.
inż. Mateusz Bondarczuk
Server and cluster infrastructure administrator
Manages computing resources, system and data security, backups and IT continuity.
dr hab. Wojciech Kwedlo
Data analysis and mining, artificial-intelligence methods
Designs solutions supporting the processing, organisation and analysis of large data sets.
dr Daniel Reska
Biomedical image analysis and processing
Parallel and distributed computing; heads the Computer Science Laboratory at the Faculty of Computer Science, Bialystok University of Technology.

Collaboration scientific

The Clinical Research Centre offers academic and industrial partners access to an integrated research platform combining clinical phenotyping, metabolic measurements and molecular analytics. We deliver projects as scientific collaborations – from joint grant applications, through cohort and interventional studies, to providing equipment and analytical expertise as research services.

Methods and research areas

Deep metabolic phenotyping, precision medicine and pharmacogenomics, genome-wide association studies (GWAS) and polygenic scores (PRS), metabolomics and multi-omic data integration, machine-learning predictive models, as well as clinical registries and clinical-trial support – from concept, through recruitment and data acquisition, to analysis.

Data resources and biobank

We maintain deeply phenotyped research cohorts and a biobank of biological material. The detailed scope of available data and resources is discussed individually – please contact us regarding collaboration.

“Research is to see what everybody has seen and to think what nobody has thought.”— Albert Szent-Györgyi, Nobel laureate in Physiology or Medicine
Equipment and infrastructure
Equipment / methodApplication
Metabolic chambers – WRICWhole-room indirect calorimetry: continuous, 24-hour measurement of energy expenditure (EE), respiratory quotient (RQ) and substrate oxidation under controlled conditions.
Indirect calorimetry – RMRMeasurement of resting metabolic rate and gas exchange (metabolic cart / canopy).
Spiroergometry / CPETExercise tests with gas-exchange analysis: VO₂max, ventilatory thresholds, VO₂ kinetics (cycle ergometers, treadmill).
High-resolution respirometry – Oroboros O2kOxygraph: mitochondrial respiration in permeabilised fibres, cells and isolated mitochondria (SUIT protocols).
Extracellular flux analysis – Seahorse XFSimultaneous measurement of oxygen consumption rate (OCR) and acidification (ECAR): glycolysis / oxidative phosphorylation profile.
Densitometry – DXAQuantitative assessment of body composition (FM / LM / BMD) and visceral-fat distribution.
Body-composition analysis – InBodyMulti-frequency bioimpedance (BIA): muscle and fat mass, hydration, segmental balance.
Immunoenzymatics – ELISA (DYNEX system)Automated, quantitative determination of hormones, proteins and biomarkers at high throughput.
Sample automation – Tecan Freedom EVORobotic liquid handling ensuring reproducibility and high assay throughput.
Molecular biologyNucleic-acid isolation, genotyping and qPCR; support for genomic and metabolomic analyses.
Continuous glucose monitoring – CGMGlucose profiles and variability indices (e.g. TIR, MAGE) in ambulatory conditions.
Biobank (−80 °C)Collection and long-term storage of biological material together with sample metadata.
Sport

Collaboration
with Jagiellonia Białystok

We work closely with the Jagiellonia Białystok football club. The players undergo regular, comprehensive testing with us – from laboratory blood analyses, through post-exercise spirometry, to exercise tests.

In the media

The Clinical Research Centre in the media

2026
Puls Medycyny

Publication in “Nature Medicine” on the genetics of obesity treatment

An international study involving Dr Łukasz Szczerbiński showed that genetic factors have only a minor effect on the effectiveness of obesity treatment – both with GLP-1 drugs and with bariatric surgery.

Read ↗
24–25.03.2026
Nauka w Polsce · ABM · TVP · Poranny · Forum Akademickie

Poland's first metabolic chambers

Two metabolic chambers have been launched at the MUB Clinical Research Support Centre – the country's first research infrastructure of this kind. They enable very precise measurement of energy metabolism, supporting research on diabetes, obesity and the effectiveness of new therapies. The investment (about PLN 7.5 million) was co-funded by the Medical Research Agency from NRRP funds.

Nauka w Polsce ↗ ABM ↗ Poranny ↗ TVP ↗ Forum Akademickie ↗
27.10.2024
Polskie Radio Białystok

Over 6,000 participants in the “Stop Diabetes” project

Over 6,000 people have already joined the PolReD registry. Participants receive a full set of free tests – including abdominal MRI, energy-expenditure measurement and an exercise test.

Read ↗
11.01.2023
Radio Akadera

Recruitment for a research project for people with obesity

The Clinical Research Centre invited people aged 18–65 with a high BMI and abnormal glucose to take part in a project studying modern obesity treatment.

Read ↗
27.09.2022
Polskie Radio Białystok

A project for people with obesity and prediabetes

The Clinical Research Centre began a three-month study for obese patients with prediabetes.

Listen ↗
23.11.2021
Polskie Radio Białystok

Launch of the “Stop Diabetes! PolReD” project

The Medical University of Bialystok invited patients with diabetes to free tests as part of the Polish Diabetes Registry – one of the Unit's pillars.

Listen ↗
Clinical Research Centre

Get to know us

Explore the full offer of the Clinical Research Centre of the Medical University of Bialystok – projects, laboratories and collaboration opportunities.

Go to the Centre's website
ul. M. Skłodowskiej-Curie 24a · 15-276 Białystok
cbk@umb.edu.pl